Mediators of Inflammation / 2013 / Article / Fig 3

Research Article

Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent

Figure 3

Expression levels of HMGB1 and its receptors after MI/R (30 min/24 hrs). (a) A moderate up-regulation of HMGB1 mRNA can be detected in the area not at risk (ANAR) of TLR2−/− animals, (b) accompanied by increased HMGB1 plasma levels. Expression levels of RAGE (c, d) or TLR9 (e) were not significantly different between genotypes while TLR2−/− animals showed an up-regulation of TLR4 mRNA (f) compared to WT in ANAR and AR. , ANAR area not at risk, AR area at risk.
174168.fig.003a
(a)
174168.fig.003b
(b)
174168.fig.003c
(c)
174168.fig.003d
(d)
174168.fig.003e
(e)
174168.fig.003f
(f)

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.