Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent
Expression levels of HMGB1 and its receptors after MI/R (30 min/24 hrs). (a) A moderate up-regulation of HMGB1 mRNA can be detected in the area not at risk (ANAR) of TLR2−/− animals, (b) accompanied by increased HMGB1 plasma levels. Expression levels of RAGE (c, d) or TLR9 (e) were not significantly different between genotypes while TLR2−/− animals showed an up-regulation of TLR4 mRNA (f) compared to WT in ANAR and AR. , ANAR area not at risk, AR area at risk.