Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent
Patients undergoing coronary artery bypass surgery with extracorporeal circulation displayed increased HMGB1 serum levels on day 3 after surgery compared to baseline ( versus bsl). Heterozygous carriers of the less-functional Arg753Gln TLR2 polymorphism showed significantly higher levels compared to healthy controls (con). –10, versus con.
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