Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection

Table 4

Kinetics of inflammatory molecules in patients with bacterial infection during antibiotic therapy.

Analyte (pg/mL)	Day 1	Day 3	Day 7	Control	𝑃 value
IL-1Ra	11,618*	3,247	2,604	1,544	<0.001
	(42,790)	(11,492)	(8,607)	(8,768)
IL-2	22.5*	21.4*	19.5*	11.9	<0.013
	(36.5)	(57.4)	(71.2)	(26.1)
IL-6	39.1*	1.9	0.4	0.4	<0.001
	(1,597)	(150)	(95.8)	(0.0)
IL-8	26.6*	21.2	14.6	6.9	<0.039
	(350)	(648)	(58)	(54)
TNF-𝛼	10.8*	5.5	4.5	0.6	<0.020
	(61.0)	(31.2)	(16.8)	(25.8)
MCP-1	326	187	231	205	n.s.
	(7,524)	(210)	(287)	(279)
MIP-1𝛽	91.0*	76.8	60.4	54.6	<0.025
	(1,699)	(275)	(161)	(91.2)

Data are presented as median (range); n.s.: not significant; *𝑃<0.05, time point versus control.