Mediators of Inflammation / 2013 / Article / Fig 3

Research Article

Lipoxin A4 Preconditioning and Postconditioning Protect Myocardial Ischemia/Reperfusion Injury in Rats

Figure 3

Transmission electron microscopy ((a)–(f)) and histological study ((g)–(l), He ×400) of cardiac tissues from rats of different groups at T2 time point. (a) Group C1 and (b) group C2: regular myocardial myofilament arrangement, clear intercalated disk structure, normal mitochondrial morphology, and structure with endoplasmic reticulum embedded in myofilament matrix; (c) group I/R1 and (d) group I/R2: disordered arrangement of myofilament, a large number of myofilament fractured, intercalated disk structure unclear, and abnormal mitochondrial morphology (a high degree of swelling, membrane lysis, fuzzy ridge structure, formation of vacuoles, and endoplasmic reticulum vacuolization); (e) group LX1 and (f) group LX2: myofilament arrangement is a little sparse, the intercalated disk structure is slightly fuzzy, and slightly swollen mitochondria; (g) group C1 and (h) group C2: normal size cardiomyocyte, no hemorrhage, or neutrophil granulocyte infiltration; (i) group I/R1 and (j) group I/R2: Cardiomyocyte degeneration, hemorrhage, edema, and significant interstitial neutrophil granulocyte infiltration; (k) group LX1 and (l) group LX2: no significant cardiomyocyte degeneration, no obvious bleeding, slight edema between the myocardial fibers, and mild neutrophil granulocyte infiltration.
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