Aged Garlic Extract Improves Adiponectin Levels in Subjects with Metabolic Syndrome: A Double-Blind, Placebo-Controlled, Randomized, Crossover Study
Table 1
Baseline demographic, anthropometrical, endothelial function and biochemical characteristics of the general population.
Variable
Global
AGE-placebo Group ()
Placebo-AGE group ()
value
Age (years)
40.79 (10.71)
44.75 (10.5)
37.34 (9.8)
0.02*,Ψ
SBP (mm Hg)
123.73 (15.63)
127 (15)
120 (15)
0.15*
DBP (mm Hg)
81.59 (10.86)
82 (12)
80 (9)
0.56*
BMI (kg/m2)
33.07 (5.01)
33.7 (5.4)
32.5 (4.5)
0.54*
WC (cm)
100.44 (10.32)
102.4 (11.6)
98.7 (8.8)
0.23*
HC (cm)
109.42 (8.89)
108.8 (8.4)
109.8 (9.4)
0.46*
Glucose (mg/dL)
87.12 (14.99)
91.85 (17.53)
83 (11.19)
0.10*
Cholesterol (mg/dL)
198.61 (30.82)
201.9 (36.61)
195.73 (25.24)
0.51*
LDL (mg/dL)
116.96 (28.16)
119.25 (35.10)
114.95 (20.98)
0.61*
HDL (mg/dL)
37.47 (5.68)
37.51 (6.55)
37.42 (4.94)
0.87*
TAG (mg/dL)
220.91 (71.96)
225.65 (80.07)
216.78 (65.65)
0.88#
CRP (mg/L)
5.79 (4.73)
7.04 (5.73)
4.70 (3.39)
0.21*
IL-6 (units/mL)
1.97 (0.88)
1.93 (0.87)
2.00 (0.90)
0.68*
Adiponectin (ng/mL)
5936.56 (1813.74)
5516.7 (1665.24)
6301.65 (1893.59)
0.15*
Leptin (ng/mL)
26.19 (19.28)
27.29 (18.64)
25.22 (20.17)
0.60#
Insulin (μU/mL)
22.26 (25.87)
28.81 (36.07)
16.58 (9.03)
0.10#
HOMA index
5.04 (6.51)
6.82 (9.03)
3.49 (2.22)
0.05#
FMV (%)
11.06 (5.98)
10.68 (5.39)
11.38 (6.37)
0.70*
SBP: systolic blood pressure; DBP: diastolic blood pressure; BMI: body mass index; WC: waist circumference; HC: hip circumference, LDL-C: low density lipoprotein cholesterol; HDL-C: high density lipoprotein cholesterol; TG: triglycerides; CRP: C-reactive protein; IL-6: interleukin-6; FMV: flow-mediated vasodilatation. Values are expressed as mean ± SD. *AGE group versus placebo group with independent Student’s -test. #AGE group versus placebo group with Wilcoxon signed-ranks test. .
