Research Article

Pharmacological Inhibition of p38 Mitogen-Activated Protein Kinases Affects KC/CXCL1-Induced Intraluminal Crawling, Transendothelial Migration, and Chemotaxis of Neutrophils In Vivo

Figure 1

Effect of SB203580 on KC-induced neutrophil rolling. (a) Time course of the velocity of neutrophil rolling (μm/sec) triggered by KC in the absence (control, white) and in the presence (black) of p38 MAPK inhibitor SB203580 (100 nM) 30 min prior to and 60 min following the placement of KC-containing gel. Data are means ± SEM ( ). (b) Time course of the flux of rolling neutrophils (cells/min) triggered by KC in the absence (control, white) and in the presence (black) of p38 MAPK inhibitor SB203580 (100 nM) 30 min prior to and 60 min following the placement of KC-containing gel. Data are means ± SEM ( ).
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