Sildenafil (Viagra) Protective Effects on Neuroinflammation: The Role of iNOS/NO System in an Inflammatory Demyelination Model

Figure 8

Luxol Fast Blue (LFB) staining ((a)–(c)) and electron micrographs ((d)–(i)). (a), (d), and (g) represent iNOS^−/− control group; (b), (e), and (h) represent CPZ-treated animals; (c), (f), and (i) represent CPZ + Sild-treated animals. Arrows in (a), (c): vacuoles in the white matter; arrowhead in (b): spaces between fibers; arrows in (d), (e), (g), and (h): damaged myelin sheath; arrowheads in (f), (i): preserved myelin. Bars = 20 μm ((a)–(c)); 2 μm ((d)–(f)); 0.5 μm ((g)–(i)).

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