Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism
Figure 10
COX-2 expression levels in spinal cord. On the 14th day the spinal cord of PPAR- and PPAR- mice was analyzed by western blot. Upper panel shows the densitometric quantification of COX-2 levels in CCI vehicle-treated animal in comparison with CCI mice repetitively treated with PEA (30 mg kg−1 s.c. daily). Values were normalized to -actin immunoreactivity. Data are expressed as the mean ± SEM of triplicate determinations performed on 5 animals for each group. was considered as significantly different from vehicle (+/+).
