Research Article

4-Methoxycarbonyl Curcumin: A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation

Figure 2

Inhibition of IL-1β levels by curcumin and CMC 2.5 in PBMC cells. PBMC cells (5 × 105 cells/well) were cultured in serum-free media (37°C, 95% air, 5% CO2) for 18 hours with LPS (P. gingivalis, 50 ng/mL) or vehicle alone. Curcumin or CMC 2.5 was added at final concentrations of 2 or 5 μM. Conditioned medium was analysed for IL-1β by ELISA. Each value represents the mean of 3 cultures ± S.E.M. * represents the significance of all groups of curcumin and CMC 2.5 compared to LPS alone; ** represents the significance between LPS + 2 μM curcumin and LPS + 2 μM CMC 2.5.
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