4-Methoxycarbonyl Curcumin: A Unique Inhibitor of Both Inflammatory Mediators and Periodontal Inflammation
Figure 7
The effect of diabetes and orally administered CMC 2.5 on plasma MMPs. Male Sprague-Dawley rats () were injected i.v. with streptozotocin (STZ) 70 mg/kg to induce diabetes, as described by us previously. STZ-diabetic rats were daily administered by oral gavage CMC 2.5 (100 mg/kg) for 3 weeks. At the end of the treatment protocol, rats were sacrificed by exsanguination; blood samples were collected and analyzed for MMP-9 by gelatin zymography and MMP-13 by Western blot, and were scanned densitometrically to quantify the levels of MMP-9 and MMP-13. *.
