Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis
Table 4
Distribution of IL8 haplotypes (arranged as genotypes) in the studied groups.
Haplotypes (genotypes of IL8 SNPs) −251T/A, +396T/G, +781C/T/251T/A, +396T/G, and +781C/T
Controls (%)
CP (%)
OR (95% CI)
AgP (%)
OR (95% CI)
TTC/TTC
42 (26.9)
86 (30.9)
NS
1.18 (0.74–1.87)
17 (29.3)
NS
0.98 (0.46–2.09)
AGT/TTC
63 (40.4)
101 (36.3)
NS
0.80 (0.52–1.23)
24 (41.4)
NS
1.13 (0.57–2.24)
ATT/TTC
6 (3.8)
3 (1.1)
0.08
0.22 (0.05–1.06)
2 (3.4)
NS
1.03 (0.19–5.49)
TGC/TTC
4 (2.6)
1 (0.4)
0.046
0.09 (0.01–0.96)
0 (0.0)
NS
*
AGC/TTC
5 (3.2)
6 (2.2)
NS
0.90 (0.24–3.36)
1 (1.7)
NS
0.64 (0.07–6.00)
ATC/TTC
0 (0.0)
6 (2.2)
0.08
*
1 (1.7)
*
*
TTT/TTC
0 (0.0)
3 (1.1)
NS
*
0 (0.0)
*
*
TGT/TTC
0 (0.0)
1 (0.4)
*
*
0 (0.0)
*
*
AGT/AGT
20 (12.8)
47 (16.9)
NS
1.60 (0.87–2.93)
10 (17.2)
NS
1.12 (0.42–3.04)
ATT/AGT
1 (0.6)
5 (1.8)
NS
2.12 (0.20–22.08)
1 (1.7)
*
3.36 (0.20–55.97)
AGT/TGC
4 (2.6)
3 (1.1)
NS
0.31 (0.06–1.52)
0 (0.0)
NS
*
AGT/AGC
1 (0.6)
5 (1.8)
NS
3.28 (0.35–30.98)
1 (1.7)
*
5.06 (0.29–87.00)
AGT/ATC
1 (0.6)
4 (1.4)
NS
2.52 (0.27–23.83)
0 (0.0)
*
*
ATT/ATT
4 (2.6)
1 (0.4)
0.07
0.17 (0.02–1.59)
0 (0.0)
NS
*
TGC/TGC
3 (1.9)
3 (1.1)
NS
0.71 (0.13–3.82)
1 (1.7)
NS
1.21 (0.12–12.26)
ATT/ATC
1 (0.6)
0 (0.0)
*
*
0 (0.0)
*
*
ATC/ATC
1 (0.6)
0 (0.0)
*
*
0 (0.0)
*
*
TGT/TGT
0 (0.0)
1 (0.4)
*
*
0 (0.0)
*
*
AGC/TGC
0 (0.0)
1 (0.4)
*
*
0 (0.0)
*
*
= 0.067
= NS
OR: odds ratio adjusted for age, sex, and smoking in logistic regression; CI: confidence intervals.
aDifferences between individual haplotypes (between controls and CP or controls and AgP) were analyzed using the Fisher exact test.
bDifferences between individual haplotypes (between controls and CP or controls and AgP) were analyzed using the test.
*OR not calculated because of the presence of zero values. Bold: significant result.
