Melatonin Improves Outcomes of Heatstroke in Mice by Reducing Brain Inflammation and Oxidative Damage and Multiple Organ Dysfunction

Table 1

Effects of heat exposure on body core temperatures of different groups of mice.

Treatment groups	Core temperature (°C)	𝑃 values
(1) Nonheated mice untreated	37.2±0.3
(2) Heated mice treated with vehicle saline	33.2±0.2	^a𝑃<0.01
(3) Heated mice treated with melatonin 0.2 mg/kg	33.5±0.3	^a𝑃<0.01
(4) Heated mice treated with melatonin 1 mg/kg	36.3±0.3	^b𝑃<0.01
(5) Heated mice treated with melatonin 5 mg/kg	37.4±0.4	^b𝑃<0.01

Core temperatures were measured 4 hours after whole body heating for heated groups or the equivalent time period for non-heated groups. ^aCompared with non-heated groups; ^bCompared with group 2. Data are means ± S.E.M. of 12 mice per group.