Melatonin Improves Outcomes of Heatstroke in Mice by Reducing Brain Inflammation and Oxidative Damage and Multiple Organ Dysfunction
Effects of heat exposure on hypothalamic levels of various parameters in different groups of mice.
MPO activity (pg/wet tissue)
() Non-heated mice
() Heated mice treated with vehicle solution
() Heated mice treated with melatonin 0.2 mg/kg
() Heated mice treated with melatonin 1 mg/kg
() Heated mice treated with melatonin 5 mg/kg
Samples were measured 4 hours after whole body heating for non-heated groups. aCompared with non-heated groups (); bCompared with group 2 (). Data are means ± S.E.M. of 12 mice per group.
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