Mediators of Inflammation / 2013 / Article / Tab 3

Research Article

Melatonin Improves Outcomes of Heatstroke in Mice by Reducing Brain Inflammation and Oxidative Damage and Multiple Organ Dysfunction

Table 3

Effects of heat exposure on hypothalamic levels of various parameters in different groups of mice.

Treatment groupsTNF-α (pg/g)IL-1β (pg/g)IL-10 (pg/g)MPO activity (pg/wet tissue)

( ) Non-heated mice
( ) Heated mice treated with vehicle solution
( ) Heated mice treated with melatonin 0.2 mg/kg
( ) Heated mice treated with melatonin 1 mg/kg
( ) Heated mice treated with melatonin 5 mg/kg

Samples were measured 4 hours after whole body heating for non-heated groups. aCompared with non-heated groups ( ); bCompared with group 2 ( ). Data are means ± S.E.M. of 12 mice per group.

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