Research Article

Melatonin Improves Outcomes of Heatstroke in Mice by Reducing Brain Inflammation and Oxidative Damage and Multiple Organ Dysfunction

Table 4

Effects of heat exposure on hypothalamic levels of various parameters in different groups of mice.

Treatment groups MDA (n mol/mg protein)GSSG/GSHGP (m U/mg protein)GR (m U/mg protein)

( ) Non-heated mice
( ) Heated mice treated with vehicle solution
( ) Heated mice treated with melatonin 0.2 mg/kg
( ) Heated mice treated with melatonin 1 mg/kg
( ) Heated mice treated with melatonin 5 mg/kg

Samples were measured 4 hours after whole body heating for non-heated groups. aCompared with non-heated groups ( ); bCompared with group 2 ( ). Data are means ± S.E.M. of 12 mice per group.