Melatonin Improves Outcomes of Heatstroke in Mice by Reducing Brain Inflammation and Oxidative Damage and Multiple Organ Dysfunction

Table 6

Effect of heat exposure on serum levels of adrenocorticotrophic-hormone (ACTH) and corticosterone in different groups of mice.

Treatment groups	ACTH (pg·mL^−1)	Corticosterone (ng·mL^−1)
(1) Non-heated mice	392±98	142±24
(2) Heated mice treated with vehicle solution	984±127^a	505±26^a
(3) Heated mice treated with melatonin 0.2 mg/kg	1001±145	518±28
(4) Heated mice treated with melatonin 1 mg/kg	1668±162^b	719±31^b
(5) Heated mice treated with melatonin 5 mg/kg	2167±176^b	854±35^b

Samples were measured 4 hours after whole body heating or the equivalent time period for non-heated groups. ^aCompared with non-heated group (𝑃<0.05); ^bCompared with group 2 (𝑃<0.05). Data are means ± S.E.M. of 12 mice per group.