The Mechanism of Sevoflurane Preconditioning-Induced Protections against Small Intestinal Ischemia Reperfusion Injury Is Independent of Mast Cell in Rats

Figure 6

MDA contents and SOD activities and p47^phox and gp91^phox protein expressions in intestine mucosa after IIR injury. SH group (Sham-operated group), IIR group (75 min intestinal ischemia and 2 h reperfusion), IIR + CP group (IIR group + Compound 48/80 1 mg/kg), IIR + CS group (50 mg/kg cromolyn sodium treated IIR group), IIR + CS + CP group (50 mg/kg cromolyn sodium treated IIR group + Compound 48/80 1 mg/kg), SEV + IIR group (2.3% sevoflurane pretreated IIR group), and SEV + IIR + CP group (2.3% sevoflurane pretreated IIR group + Compound 48/80 1 mg/kg). Bar graph (a) quantified MDA contents and bar graph (b) quantified SOD activities, 𝑛=6 per group. Representative bands of p47^phox and gp91^phox protein expressions are displayed in (c). Bar graphs (d) and (e) quantified p47^phox and gp91^phox protein expressions, respectively (𝑛=3). Results are expressed as Mean ± SEM. ^∗𝑃<0.05 versus SH group, ^#𝑃<0.05 versus IIR group, ^$𝑃<0.05 versus IIR + CP group, ^&𝑃<0.05 versus IIR + CS group, and ^∧𝑃<0.05 versus SEV + IIR group.

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