Carrageenan-Induced Colonic Inflammation Is Reduced in Bcl10 Null Mice and Increased in IL-10-Deficient Mice
Figure 4
Carrageenan-induced increase in RelA is reduced and is absent in RelB in Bcl10 null mice. (a) Nuclear RelA, measured by oligonucleotide assay, increased by ~89% in the wild type and heterozygous mice following carrageenan but only by about 40% in the Bcl10 null mice (). (b) In contrast, the increase in RelB was completely inhibited in the Bcl10 null mice but increased by ~75% in the heterozygous and wild type mice following carrageenan (). CGN: carrageenan; WT: wild-type; Het: heterozygous; N.D.: no difference.
