Regulation and Prognostic Relevance of Symmetric Dimethylarginine Serum Concentrations in Critical Illness and Sepsis
Figure 3
Prediction of mortality by SDMA serum concentrations. ((a)-(b)) Kaplan-Meier survival curves of ICU patients are displayed, showing that patients with SDMA levels of upper quartile (on admission >1.7 μmol/L; black (a)) had an increased short-term mortality at the ICU as compared to patients with ADMA serum concentrations of lower quartile (on admission <0.51 μmol/L; light grey) or middle 50% (grey). Best discrimination between ICU survivors and nonsurvivors was achieved with an SDMA cutoff value of 1.2 μmol/L (b). Log rank and values are given in the figure. ((c)-(d)) Kaplan-Meier survival curves of ICU patients are displayed, showing that patients with SDMA levels of upper quartile (on admission >1.7 μmol/L; black (c)) had an increased long-term mortality at the ICU as compared to patients with SDMA serum concentrations of lower quartile (on admission <0.51 μmol/L; light grey) or middle 50% (grey). Best discrimination between overall survivors and nonsurvivors was achieved with an ADMA cutoff value of 0.75 μmol/L (d).
