Hypothermia Reduces Toll-Like Receptor 3-Activated Microglial Interferon-β and Nitric Oxide Production
Effects of hypothermic culture on production by poly(I:C)-stimulated rat and mouse microglia. Rat (a) and mouse (b) microglia ( cells/well) were cultured with or without 100 μg/mL poly(I:C) under hypothermic (33°C) and normothermic (37°C) conditions for 48 h. levels in culture supernatants were measured using a colorimetric assay with Griess reagent. Data are expressed as ( for rat microglia (a) and for mouse microglia (b)). ** compared with 37°C.