Subclinical Cardiovascular System Changes in Obese Patients with Juvenile Idiopathic Arthritis
Table 4
Traditional cardiovascular risk factors, selected inflammatory markers, and ultrasonographic evaluation of cardiovascular system in clinically active and inactive juvenile idiopathic arthritis (JIA) patients.
JIA patients clinically active ( = 30)
JIA patients clinically inactive ( = 28)
Control group ( = 36)
value
Traditional risk factors
Age, years
12.5 (9.5–15.0)
14.0 (11.0–16.0)
13.4 (12.0–15.0)
0.24
BMI, kg/m2
20.2 (18.3–22.2)
20 (16.6–21.7)
19.4 (17.3–20.6)
0.19
BMI-SDS
1.1 (0.1–1.7)†
0.1 (−0.1–0.5)
0.1 (−0.5–0.5)
0.01
SBP, mmHg
116 (99–127)
121 (103–126)†
112 (103–117)
0.03
DBP, mmHg
68 (55–71)
65 (57–69)
64 (57–69)
0.20
Total cholesterol, mmol/L
4.2 (3.7–4.7)
3.9 (3.5–4.4)
4 (3.5–4.4)
0.48
LDL-cholesterol, mmol/L
2.2 (1.8–2.5)
2.0 (1.8–2.5)
2.0 (1.8–2.4)
0.71
HDL-cholesterol, mmol/L
1.4 (1.0–1.5)
1.3 (1.2–1.6)
1.4 (1.1–1.6)
0.51
Triglycerides, mmol/L
0.7 (0.6–1.2)
0.8 (0.5–0.9)
0.7 (0.6–0.9)
0.52
Glucose, mmol/L
4.8 (4.6–5.0)
5.0 (4.8–5.1)
4.8 (4.6–5.0)
0.21
Insulin, mU/mL
7.1 (4.8–13.3)
7.9 (3.8–10.5)
6.6 (4.0–8.8)
0.30
HOMA index
1.5 (1.0–2.7)
1.7 (0.8–2.4)
1.4 (0.8–1.9)
0.28
Inflammatory markers
hsCRP, mg/L
1.2 (0.3–4.9)†
0.8 (0.1–2.7)†
0.04 (0.01–0.2)
<0.001
Il-6, pg/mL
3.6 (1.1–7.4)†
1.4 (0.4–6.4)†
0.2 (0.2–0.8)
<0.001
TNFα, pg/mL
2.5 (0.8–17.9)†
3 (1.3–32)†
0.7 (0.7–0.72)
<0.001
Adiponectin, g/mL
10.9 (8.0–13.9)
11.0 (8.0–14.0)
12.5 (8.0–16.0)
=0.640
Ultrasonographic studies
Brachial artery, mm
3.7 (3.3–3.9)
3.8 (3.4–4.5)
3.6 (3.2–4.2)
=0.230
FMD, %
7.8 (6.2–9.6)†
8.1 (2.7–8.9)†
11.1 (9.2–12.6)
<0.001
IMT, mm
0.49 (0.43–0.51)†
0.53 (0.44–0.56)†
0.42 (0.39–0.45)
<0.001
LVMi, g/m2.7
27.6 (25.1–29.9)†
27.6 (18.8–29.1)
22.9 (19.2–28.3)
=0.040
Values are presented as median (interquartile range), SBP: systolic blood pressure, DBP: diastolic blood pressure, HOMA index: index of insulin resistance, FMD: flow mediated dilatation of the right brachial artery, IMT: intima-media thickness of the common carotid arteries, and LVMi: indexed left ventricle mass. ANOVA Kruskal-Wallis test. in comparison to the control group in post-hoc test. clinically active versus inactive groups in post-hoc test.
