A Subanesthetic Dose of Isoflurane during Postconditioning Ameliorates Zymosan-Induced Neutrophil Inflammation Lung Injury and Mortality in Mice

Figure 7

Effects of 0.7% ISO treatment on chemokine production, endothelial adhesion protein expression, and neutrophil recruitment in ZY-treated lung at 24 hrs. Levels of the following chemokines in BALF were measured by ELISA: (a) keratinocyte-derived chemokine (KC); (b) macrophage inhibitory protein-1α (MIP-1α); (c) macrophage inhibitory protein-2 (MIP-2); (d) monocyte chemoattractant protein-1 (MCP-1). The mRNA expression of the following endothelial adhesion molecules in lung tissue from all groups was measured by qPCR: (e) E-selectin; (f) ICAM-1; (g) VCAM-1. Lung MPO activity is shown in (h). The animals were treated as shown in Figure 1(a). Data represent mean ± SD (𝑛=10mice per group).^∗𝑃<0.05versus sham + vehicle;^#𝑃<0.05versus ZY + vehicle.

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