TNF and TNF Receptor Superfamily Members in HIV infection: New Cellular Targets for Therapy?

Figure 1

TNF and TNFR superfamily-mediated cell signaling. Binding of TNF-alpha to TNFRs results in activation of its receptors followed by recruitment of adaptor proteins (TRADD, FADD, TRAF, and RIP) in sequential manner that activates several signaling cascades leading to the activation of transcription factors NF-kappaB, AP-1, and/or caspase cascades. Most of the members of TNF superfamily activate also NF-kappaB.