Overview of Community-Acquired Pneumonia and the Role of Inflammatory Mechanisms in the Immunopathogenesis of Severe Pneumococcal Disease
Table 3
Adjunctive anti-inflammatory therapies in CAP.
Type of adjunctive therapy
Current status
Macrolide antibiotics
Recommended in current guidelines primarily for antimicrobial activity. The clinical relevance of anti-inflammatory activity remains to be conclusively established
Corticosteroids
Remains controversial and is the subject of several ongoing randomised, prospective, controlled trials
Statins
Show promise, but therapeutic efficacy of initiation at the time of diagnosis of CAP remains to be established
cAMP-elevatory agents
Theoretically promising, although few safe and effective agents currently available; salbutamol found ineffective in the treatment of ALI
