NF-𝜿B Inhibition after Cecal Ligation and Puncture Reduces Sepsis-Associated Lung Injury without Altering Bacterial Host Defense

Figure 3

NF-𝜅B inhibition reduces lung inflammation after CLP. (a) Total cells, (b) neutrophils, and (c) KC levels in BAL at 24 hours after surgery in control mice treated with sham laparotomy (Ctrl), mice that underwent CLP followed by vehicle (CLP), and mice treated with CLP followed by BMS-345541 (CLP+BMS). 𝑁=10 per group. *𝑃<0.05 for CLP versus sham laparotomy controls (Ctrl); ^#𝑃<0.05 for CLP+BMS versus CLP. (d) Serum cytokine levels for KC, MCP-1, and IL-10 at 24 hours after surgery. 𝑁=5 per group. *𝑃<0.05 for CLP versus Ctrl; ^#𝑃<0.05 for CLP+BMS versus CLP. Results are presented as mean ± SE.

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