High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice: A Protective Role for PPAR-δ Agonism

Figure 1

Effects of dietary manipulation and GW0742 treatment on PPAR-𝛿 expression in the mouse gastrocnemius. Protein expression was measured by western blot analysis in gastrocnemius homogenates of mice fed with a standard (control) or HFCS diet (HFCS) in the absence or presence of GW0742 treatment (1 mg/kg/day) (control+GW; HFCS+GW). Densitometric analysis of the bands is expressed as relative optical density (O.D.), corrected for the corresponding tubulin, and normalized using the related control band. Data are means±SD of three separate experiments. *𝑃<0.01 versus HFCS.