Poly (ADP-Ribose) Polymerase Mediates Diabetes-Induced Retinal Neuropathy

<table>Effect of 1,5-isoquinolinediol on retinal ERK<sub>1/2</sub> activation in diabetes. Relative abundance of phosphorylated ERK<sub>1/2</sub> (p-ERK<sub>1/2</sub>) and total ERK<sub>1/2</sub> (<svg height="10.3875" id="M4" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 5.9250002 10.3875" width="5.9250002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>-ERK<sub>1/2</sub>) was determined by Western blotting, followed by densitometry.  Data are expressed as percentage change in phosphorylation over <svg height="10.3875" id="M5" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 5.9250002 10.3875" width="5.9250002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>-ERK<sub>1/2</sub> and are expressed as mean ± SD. Values obtained from nondiabetic rats are considered as 100%. N: nondiabetic rat; D: diabetic rat; D + IQ: diabetic rat treated with 1,5-isoquinolinediol. <svg height="13.95" id="M6" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared with nondiabetic rat. <svg height="15.775" id="M7" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 67.387497 15.775" width="67.387497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared with diabetic rat.</table>

Mediators of Inflammation

fig2

Figure 2

Figure 2: Poly (ADP-Ribose) Polymerase Mediates Diabetes-Induced Retinal Neuropathy 