Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2013 (2013), Article ID 518183, 12 pages
http://dx.doi.org/10.1155/2013/518183
Research Article

IRAK1/4-Targeted Anti-Inflammatory Action of Caffeic Acid

1Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea
2Anti-aging Research Institute, BIO-FD&C Co., Ltd, Incheon 406-840, Republic of Korea

Received 4 September 2013; Accepted 29 October 2013

Academic Editor: Satoru Yui

Copyright © 2013 Woo Seok Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. W. Kinne, R. Bräuer, B. Stuhlmüller, E. Palombo-Kinne, and G.-R. Burmester, “Macrophages in rheumatoid arthritis,” Arthritis Research, vol. 2, no. 3, pp. 189–202, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Owens, A. A. Babcock, J. M. Millward, and H. Toft-Hansen, “Cytokine and chemokine inter-regulation in the inflamed or injured CNS,” Brain Research Reviews, vol. 48, no. 2, pp. 178–184, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Sekine, T. Yumioka, T. Yamamoto et al., “Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages,” Journal of Immunology, vol. 176, no. 1, pp. 380–389, 2006. View at Google Scholar · View at Scopus
  4. K. Takeda and S. Akira, “Roles of Toll-like receptors in innate immune responses,” Genes to Cells, vol. 6, no. 9, pp. 733–742, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. B. Bresnihan, “Pathogenesis of joint damage in rheumatoid arthritis,” Journal of Rheumatology, vol. 26, no. 3, pp. 717–719, 1999. View at Google Scholar · View at Scopus
  6. G. R. Burmester, B. Stuhlmüller, G. Keyszer, and R. W. Kinne, “Mononuclear phagocytes and rheumatoid synovitis: mastermind or workhorse in arthritis?” Arthritis and Rheumatism, vol. 40, no. 1, pp. 5–18, 1997. View at Publisher · View at Google Scholar · View at Scopus
  7. J. A. Gracie, R. J. Forsey, W. L. Chan et al., “A proinflammatory role for IL-18 in rheumatoid arthritis,” Journal of Clinical Investigation, vol. 104, no. 10, pp. 1393–1401, 1999. View at Google Scholar · View at Scopus
  8. Y. W. Lee, H. J. Cho, W. H. Lee, and W. E. Sonntag, “Whole brain radiation-induced cognitive impairment: pathophysiological mechanisms and therapeutic targets,” Biomolecules & Therapeutics, vol. 20, no. 4, pp. 357–370, 2012. View at Google Scholar
  9. V. Magrioti and G. Kokotos, “Phospholipase A2inhibitors as potential therapeutic agents for the treatment of inflammatory diseases,” Expert Opinion on Therapeutic Patents, vol. 20, no. 1, pp. 1–18, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. S. E. Byeon, Y. S. Yi, J. Oh, B. C. Yoo, S. Hong, and J. Y. Cho, “The role of Src kinase in macrophage-mediated inflammatory responses,” Mediators of Inflammation, vol. 2012, Article ID 512926, 18 pages, 2012. View at Publisher · View at Google Scholar
  11. T. Yu, Y. S. Yi, Y. Yang, J. Oh, D. Jeong, and J. Y. Cho, “The pivotal role of TBK1 in inflammatory responses mediated by macrophages,” Mediators of Inflammation, vol. 2012, Article ID 979105, 8 pages, 2012. View at Publisher · View at Google Scholar
  12. S. C. Gupta, J. H. Kim, S. Prasad, and B. B. Aggarwal, “Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals,” Cancer and Metastasis Reviews, vol. 29, no. 3, pp. 405–434, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Rajendra Prasad, A. Karthikeyan, S. Karthikeyan, and B. Venkata Reddy, “Inhibitory effect of caffeic acid on cancer cell proliferation by oxidative mechanism in human HT-1080 fibrosarcoma cell line,” Molecular and Cellular Biochemistry, vol. 349, no. 1-2, pp. 11–19, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. S. H. Yim, H. J. Kim, S. H. Park et al., “Cytotoxic caffeic acid derivatives from the rhizomes of Cimicifuga heracleifolia,” Archives of Pharmacal Research, vol. 35, no. 9, pp. 1559–1565, 2012. View at Google Scholar
  15. K. M. Lee, H. S. Kang, C. H. Yun, and H. S. Kwak, “Potential in vitro protective effect of quercetin, catechin, caffeic acid and phytic acid against ethanol-induced oxidative stress in SK-Hep-1 cells,” Biomolecules & Therapeutics, vol. 20, no. 5, pp. 492–498, 2012. View at Google Scholar
  16. R. Feng, Y. Lu, L. L. Bowman, Y. Qian, V. Castranova, and M. Ding, “Inhibition of activator protein-1, NF-κB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid,” Journal of Biological Chemistry, vol. 280, no. 30, pp. 27888–27895, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. P. J. Morin, D. Ferguson, L. M. Leblanc et al., “NMR metabolomics analysis of the effects of 5-lipoxygenase inhibitors on metabolism in glioblastomas,” Jouranl of Proteome Research, vol. 12, no. 5, pp. 2165–2176, 2013. View at Publisher · View at Google Scholar
  18. Z. H. Shi, N. G. Li, Q. P. Shi et al., “Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors,” Bioorganic & Medicinal Chemistry Letters, vol. 23, no. 5, pp. 1206–1211, 2013. View at Google Scholar
  19. J. Anwar, R. M. Spanevello, V. C. Pimentel et al., “Caffeic acid treatment alters the extracellular adenine nucleotide hydrolysis in platelets and lymphocytes of adult rats,” Food and Chemical Toxicology, vol. 56, pp. 459–466, 2013. View at Publisher · View at Google Scholar
  20. N. J. Kang, K. W. Lee, B. J. Shin et al., “Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression,” Carcinogenesis, vol. 30, no. 2, pp. 321–330, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Dalby-Brown, H. Barsett, A.-K. R. Landbo, A. S. Meyer, and P. Mølgaard, “Synergistic antioxidative effects of alkamides, caffeic acid derivatives, and polysaccharide fractions from Echinacea purpurea on in vitro oxidation of human low-density lipoproteins,” Journal of Agricultural and Food Chemistry, vol. 53, no. 24, pp. 9413–9423, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Meghashri and S. Gopal, “Biochemical characterization of radical scavenging polyphenols from Nyctanthes arbortristis,” Journal of Pharmacy & Bioallied Sciences, vol. 4, no. 4, pp. 341–344, 2012. View at Google Scholar
  23. R. Rajamurugan, N. Selvaganabathy, S. Kumaravel et al., “Identification, quantification of bioactive constituents, evaluation of antioxidant and in vivo acute toxicity property from the methanol extract of Vernonia cinerea leaf extract,” Pharmaceutical Biology, vol. 49, no. 12, pp. 1311–1320, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Pauwels, J. Balzarini, M. Baba et al., “Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds,” Journal of Virological Methods, vol. 20, no. 4, pp. 309–321, 1988. View at Google Scholar · View at Scopus
  25. C. Liang, Y. Ding, S. B. Song et al., “Oleanane-triterpenoids from Panax stipuleanatus inhibit NF-κB,” Journal of Ginseng Research, vol. 37, no. 1, pp. 74–79, 2013. View at Google Scholar
  26. J. R. Kim, D.-R. Oh, M. H. Cha et al., “Protective effect of polygoni cuspidati radix and emodin on Vibrio vulnificus cytotoxicity and infection,” Journal of Microbiology, vol. 46, no. 6, pp. 737–743, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Y. Cho, K. U. Baik, J. H. Jung, and M. H. Park, “In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa,” European Journal of Pharmacology, vol. 398, no. 3, pp. 399–407, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. T. Yayeh, K. H. Jung, H. Y. Jeong et al., “Korean red ginseng saponin fraction downregulates proinflammatory mediators in LPS stimulated RAW264. 7 cells and protects mice against endotoxic shock,” Journal of Ginseng Research, vol. 36, no. 3, pp. 263–269, 2012. View at Google Scholar
  29. T. Yu, Y. J. Lee, H. M. Yang et al., “Inhibitory effect of Sanguisorba officinalis ethanol extract on NO and PGE2 production is mediated by suppression of NF-κB and AP-1 activation signaling cascade,” Journal of Ethnopharmacology, vol. 134, no. 1, pp. 11–17, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. D. H. Kim, J. H. Chung, J. S. Yoon et al., “Ginsenoside Rd inhibits the expressions of iNOS and COX-2 by suppressing NF-κB in LPS-stimulated RAW264. 7 cells and mouse liver,” Journal of Ginseng Research, vol. 37, no. 1, pp. 54–63, 2013. View at Google Scholar
  31. Y. Jang, Y. Lee, S. M. Kim, Y. D. Yang, J. Jung, and U. Oh, “Quantitative analysis of TRP channel genes in mouse organs,” Archives of Pharmacal Research, vol. 35, no. 10, pp. 1823–1830, 2012. View at Google Scholar
  32. Y. J. Kim, O. R. Lee, S. Lee, K. T. Kim, and D. C. Yang, “Isolation and characterization of a theta glutathione S-transferase gene from Panax ginseng Meyer,” Journal of Ginseng Research, vol. 36, no. 4, pp. 449–460, 2012. View at Google Scholar
  33. M. Jin, S. Park, and M. Y. Pyo, “Suppressive effects of T-412, a flavone on interleukin-4 production in T cells,” Biological and Pharmaceutical Bulletin, vol. 32, no. 11, pp. 1875–1879, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. K. K. Jung, H. S. Lee, J. Y. Cho et al., “Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia,” Life Sciences, vol. 79, no. 21, pp. 2022–2031, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. S. E. Byeon, Y. G. Lee, B. H. Kim et al., “Surfactin blocks NO production in lipopolysaccharide-activated macrophages by inhibiting NF-κB activation,” Journal of Microbiology and Biotechnology, vol. 18, no. 12, pp. 1984–1989, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. Y. C. Jun, J. C. Gyung, W. S. Seung et al., “Isolation and antifungal activity of lignans from Myristica fragrans against various plant pathogenic fungi,” Pest Management Science, vol. 63, no. 9, pp. 935–940, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Okabe, H. Miyake, and Y. Awane, “Cytoprotective effects of NC-1300 and omeprazole on HCl·ethanol-induced gastric lesions in rats,” Japanese Journal of Pharmacology, vol. 42, no. 1, pp. 123–133, 1986. View at Google Scholar · View at Scopus
  38. C.-H. Wu, H.-W. Huang, J.-A. Lin, S.-M. Huang, and G.-C. Yen, “The proglycation effect of caffeic acid leads to the elevation of oxidative stress and inflammation in monocytes, macrophages and vascular endothelial cells,” Journal of Nutritional Biochemistry, vol. 22, no. 6, pp. 585–594, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. H. Uto-Kondo, M. Ayaori, M. Ogura et al., “Coffee consumption enhances high-density lipoprotein-mediated cholesterol efflux in macrophages,” Circulation Research, vol. 106, no. 4, pp. 779–787, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. M. K. Moon, Y. J. Lee, J. S. Kim, D. G. Kang, and H. S. Lee, “Effect of caffeic acid on tumor necrosis factor-alpha-induced vascular inflammation in human umbilical vein endothelial cells,” Biological and Pharmaceutical Bulletin, vol. 32, no. 8, pp. 1371–1377, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. B. D. Cuevas, A. N. Abell, and G. L. Johnson, “Role of mitogen-activated protein kinase kinase kinases in signal integration,” Oncogene, vol. 26, no. 22, pp. 3159–3171, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. Y. J. Liu, H. B. Fan, Y. Jin et al., “Cannabinoid receptor 2 suppresses leukocyte inflammatory migration by modulating the JNK/c-Jun/Alox5 pathway,” Journal of Biological Chemistry, vol. 288, no. 19, pp. 13551–13562, 2013. View at Publisher · View at Google Scholar
  43. M. J. Kim, N. Y. Choi, J. E. Koo et al., “Suppression of Toll-like receptor 4 activation by endogenous oxidized phosphatidylcholine, KOdiA-PC by inhibiting LPS binding to MD2,” Inflammation Research, vol. 62, no. 6, pp. 571–580, 2013. View at Publisher · View at Google Scholar
  44. J. Tian, X. Guo, X. M. Liu et al., “Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes,” Cardiovascular Research, vol. 98, no. 3, pp. 391–401, 2013. View at Publisher · View at Google Scholar
  45. J. Y. Lim, D. Sul, B. Y. Hwang, K. W. Hwang, K. Y. Yoo, and S. Y. Park, “Suppression of LPS-induced inflammatory responses by inflexanin B in BV2 microglial cells,” Canadian Journal of Physiology and Pharmacology, vol. 91, no. 2, pp. 141–148, 2013. View at Google Scholar
  46. Y. C. Cho, S. H. Lee, M. Lee et al., “Enhanced IL-12p40 production in LPS-stimulated macrophages by inhibiting JNK activation by artemisinin,” Archives of Pharmacal Research, vol. 35, no. 11, pp. 1961–1968, 2012. View at Google Scholar
  47. W. J. Yoon, S. J. Heo, S. C. Han et al., “Anti-inflammatory effect of sargachromanol G isolated from Sargassum siliquastrum in RAW 264. 7 cells,” Archives of Pharmacal Research, vol. 35, no. 8, pp. 1421–1430, 2012. View at Google Scholar
  48. S.-J. Tsai, C.-Y. Chao, and M.-C. Yin, “Preventive and therapeutic effects of caffeic acid against inflammatory injury in striatum of MPTP-treated mice,” European Journal of Pharmacology, vol. 670, no. 2-3, pp. 441–447, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. M. U Rehman and S. Sultana, “Attenuation of oxidative stress, inflammation and early markers of tumor promotion by caffeic acid in Fe-NTA exposed kidneys of Wistar rats,” Molecular and Cellular Biochemistry, vol. 357, no. 1-2, pp. 115–124, 2011. View at Google Scholar · View at Scopus
  50. A. Mehrotra, R. Shanbhag, M. R. Chamallamudi, V. P. Singh, and J. Mudgal, “Ameliorative effect of caffeic acid against inflammatory pain in rodents,” European Journal of Pharmacology, vol. 666, no. 1–3, pp. 80–86, 2011. View at Publisher · View at Google Scholar · View at Scopus