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Mediators of Inflammation
Volume 2013, Article ID 532619, 6 pages
Clinical Study

Urinary Eosinophil Protein X in Childhood Asthma: Relation with Changes in Disease Control and Eosinophilic Airway Inflammation

1Department of Pediatric Respiratory Medicine, Juliana Children’s Hospital, HAGA Teaching Hospital, P.O. Box 60605, 2506 LP, The Hague, The Netherlands
2Department of Biostatistics, Erasmus University Medical Centre, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands
3Department of Respiratory Medicine, Academic Medical University of Amsterdam, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands
4Department of Pediatric Respiratory Medicine, Beatrix Children's Hospital, University Medical Centre Groningen, P.O. Box 30001, 9700 RB, Groningen, The Netherlands
5Department of Pediatric Respiratory Medicine, Sophia Children's Hospital, Erasmus University Medical Centre, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands

Received 7 November 2012; Accepted 24 December 2012

Academic Editor: Helen C. Steel

Copyright © 2013 Marianne Nuijsink et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to assess cross-sectional and longitudinal correlations between uEPX and other markers of asthma control and eosinophilic airway inflammation. Methods. We measured uEPX at baseline, after 1 year and after 2 years in 205 atopic asthmatic children using inhaled fluticasone. At the same time points, we assessed symptom scores (2 weeks diary card), lung function (forced expiratory volume in one second (FEV1)), airway hyperresponsiveness (AHR), and percentage eosinophils in induced sputum (% eos). Results. We found negative correlations between uEPX and FEV1 at baseline ( ), after 1 year ( ) and after 2 years ( ). Within-patient changes of uEPX showed a negative association with FEV1 changes (at 1 year: ; at 2 years: ). Within-patient changes from baseline of uEPX correlated with changes in % eos. No relations were found between uEPX and symptoms. Conclusion. In this population of children with atopic asthma, uEPX correlated with FEV1 and % eos, and within-subjects changes in uEPX correlated with changes in FEV1 and % eos. As the associations were weak and the scatter of uEPX wide, it seems unlikely that uEPX will be useful as a biomarker for monitoring asthma control in the individual child.