Clinical Study

Urinary Eosinophil Protein X in Childhood Asthma: Relation with Changes in Disease Control and Eosinophilic Airway Inflammation

Table 1

Characteristics of the 205 children at baseline.

Age (y)10.4 6.4–16.8
Gender (m/f)118/87
Daily dose fluticasone 200 g/500 g116/89
uEPX ( g/mmol creatinine) ( )184 (2–3114)
Symptom-free days (%)50 (0–100)
FEV1 (% pred)97 (56–136)
PD20 methacholine ( g)72 (1–>1570.0#)
Sputum eosinophils (%) ( )1 (0–72)

Values are median (range).
FEV1: forced expiratory volume in 1 second; PD20 methacholine: provocative dose of methacholine causing FEV1 fall 20% from baseline.
#12 children had not reached the 20% fall at the highest dose of 1570 g.
79 patients had a total of 127% eos measurements combined with an uEPX measurement, and in 49 of these a baseline measurement was available.
Baseline characteristics form part of this group have been published previously in a cross-sectional study by Nuijsink et al. [13].