Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases

Figure 2

Gene transcription mechanisms of PPAR. In inactivated state, PPAR interacts with the corepressor, and this complex has Histone deacetylase activity, thus inhibiting the transcription process. After the binding of the exogenous ligand (drug) or endogenous ligand (fatty acids, prostaglandins, etc.), with the PPAR it is activated and it heterodimerizes with RXR and recruits coactivators, which have histone acetylase activity facilitating the transcription of several genes.