Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases
Figure 3
Mechanism of transcription and biological effects in different organs. (a) PPAR-γ exhibits anti-diabetic and atherosclerotic effects in adipocytes and skeletal muscle. (b) PPAR-α has multiple effects on liver, heart, and vascular wall. (c) PPAR-δ is expressed widely throughout the body and its gene expression is involved with the metabolism of lipids and glucose, as well as in decreasing the platelet activation. (Modified from [87].)