Lung-Derived Mediators Induce Cytokine Production in Downstream Organs via an NF-κB-Dependent Mechanism
Absolute increase in selected cytokine concentrations in MLEC media. G-CSF, IL-6, CXCL-1, CXCL-2, and MCP-1 concentrations from MLECs exposed to control uncirculated perfusate (open bar), lung perfusate (solid bar), and cytomix (checkered bar). (* concentration after 8 h incubation on MLEC versus concentration before incubation on MLEC (0 h), + versus control perfusate after both were incubated on MLEC cultures for 8 h, ±SEM). Where open bars are not apparent (G-CSF, IL-6, CXCL-1, CXCL-2), the increase is too small to print.