Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2013 (2013), Article ID 586895, 10 pages
http://dx.doi.org/10.1155/2013/586895
Research Article

Lung-Derived Mediators Induce Cytokine Production in Downstream Organs via an NF-κB-Dependent Mechanism

1Lawson Health Research Institute, London, ON, Canada N6A 4V2
2Department of Medicine, Physiology and Pharmacology, Western University, London, ON, Canada

Received 29 May 2012; Revised 3 January 2013; Accepted 20 February 2013

Academic Editor: Celeste C. Finnerty

Copyright © 2013 E. K. Patterson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. A. Matthay and R. L. Zemans, “The acute respiratory distress syndrome: pathogenesis and treatment,” Annual Review of Pathology, vol. 6, pp. 147–163, 2011. View at Publisher · View at Google Scholar
  2. A. S. Slutsky and L. N. Tremblay, “Multiple system organ failure: is mechanical ventilation a contributing factor?” American Journal of Respiratory and Critical Care Medicine, vol. 157, no. 6, pp. 1721–1725, 1998. View at Google Scholar · View at Scopus
  3. L. N. Tremblay and A. S. Slutsky, “Pathogenesis of ventilator-induced lung injury: trials and tribulations,” American Journal of Physiology, vol. 288, no. 4, pp. L596–L598, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. R. G. Brower, M. A. Matthay, A. Morris, D. Schoenfeld, B. T. Thompson, and A. Wheeler, “Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome,” The New England Journal of Medicine, vol. 342, no. 18, pp. 1301–1308, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. L. N. Tremblay and A. S. Slutsky, “Ventilator-induced injury: from barotrauma to biotrauma,” Proceedings of the Association of American Physicians, vol. 110, no. 6, pp. 482–488, 1998. View at Google Scholar · View at Scopus
  6. Y. Imai, J. Parodo, O. Kajikawa et al., “Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome,” JAMA, vol. 289, no. 16, pp. 2104–2112, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. E. A. Truscott, L. A. McCaig, L. J. Yao, R. A. W. Veldhuizen, and J. F. Lewis, “Surfactant protein-A reduces translocation of mediators from the lung into the circulation,” Experimental Lung Research, vol. 36, no. 7, pp. 431–439, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. M. G. Walker, J. M. Tessolini, L. McCaig, L. J. Yao, J. F. Lewis, and R. A. Veldhuizen, “Elevated endogenous surfactant reduces inflammation in an acute lung injury model,” Experimental Lung Research, vol. 35, no. 7, pp. 591–604, 2009. View at Google Scholar · View at Scopus
  9. N. Markovic, L. A. McCaig, J. Stephen et al., “Mediators released from LPS-challenged lungs induce inflammatory responses in liver vascular endothelial cells and neutrophilic leukocytes,” American Journal of Physiology, vol. 297, no. 6, pp. G1066–G1076, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. M. G. Walker, L. J. Yao, E. K. Patterson et al., “The effect of tidal volume on systemic inflammation in acid-induced lung injury,” Respiration, vol. 81, no. 4, pp. 333–342, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. G. U. Meduri, S. Headley, G. Kohler et al., “Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS: plasma IL-1β and IL-6 levels are consistent and efficient predictors of outcome over time,” Chest, vol. 107, no. 4, pp. 1062–1073, 1995. View at Google Scholar · View at Scopus
  12. T. Lawrence, “The nuclear factor NF-kappaB pathway in inflammation,” Cold Spring Harbor Perspectives in Biology, vol. 1, no. 6, Article ID a001651, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. M. S. Hayden and S. Ghosh, “NF-κB, the first quarter-century: remarkable progress and outstanding questions,” Genes and Development, vol. 26, no. 3, pp. 203–234, 2012. View at Publisher · View at Google Scholar
  14. D. K. Nakayama, D. A. Geller, C. J. Lowenstein et al., “Cytokines and lipopolysaccharide induce nitric oxide synthase in cultured rat pulmonary artery smooth muscle,” American Journal of Respiratory Cell and Molecular Biology, vol. 7, no. 5, pp. 471–476, 1992. View at Google Scholar · View at Scopus
  15. S. J. Jeong, C. A. Pise-Masison, M. F. Radonovich, U. P. Hyeon, and J. N. Brady, “A novel NF-κB pathway involving IKKβand p65/RelA Ser-536 phosphorylation results in p53 inhibition in the absence of NF-κB transcriptional activity,” The Journal of Biological Chemistry, vol. 280, no. 11, pp. 10326–10332, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Ritz and A. N. Spiess, “qpcR: an R package for sigmoidal model selection in quantitative real-time polymerase chain reaction analysis,” Bioinformatics, vol. 24, no. 13, pp. 1549–1551, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Lefever, J. Vandesompele, F. Speleman, and F. Pattyn, “RTPrimerDB: the portal for real-time PCR primers and probes,” Nucleic Acids Research, vol. 37, no. 1, pp. D942–D945, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. M. A. Hegeman, M. P. Hennus, C. J. Heijnen et al., “Ventilator-induced endothelial activation and inflammation in the lung and distal organs,” Critical Care, vol. 13, no. 6, article R182, 2009. View at Google Scholar · View at Scopus
  19. Y. Onai, J. I. Suzuki, T. Kakuta et al., “Inhibition of IκB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury,” Cardiovascular Research, vol. 63, no. 1, pp. 51–59, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. G. F. Sud'ina, O. K. Mirzoeva, M. A. Pushkareva, G. A. Korshunova, N. V. Sumbatyan, and S. D. Varfolomeev, “Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties,” FEBS Letters, vol. 329, no. 1-2, pp. 21–24, 1993. View at Publisher · View at Google Scholar · View at Scopus
  21. P. A. Baeuerle and T. Henkel, “Function and activation of NF-kappa B in the immune system,” Annual Review of Immunology, vol. 12, pp. 141–179, 1994. View at Google Scholar
  22. H. Zhao, T. Hiroi, B. S. Hansen, and J. J. Rade, “Cyclic stretch induces cyclooxygenase-2 gene expression in vascular endothelial cells via activation of nuclear factor kappa-β,” Biochemical and Biophysical Research Communications, vol. 389, no. 4, pp. 599–601, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Alessandrini, I. Beck-Speier, D. Krappmann et al., “Role of oxidative stress in ultrafine particle-induced exacerbation of allergic lung inflammation,” American Journal of Respiratory and Critical Care Medicine, vol. 179, no. 11, pp. 984–991, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Wu, W. Dong, M. Zhou et al., “Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats,” American Journal of Respiratory and Critical Care Medicine, vol. 176, no. 8, pp. 805–813, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. L. N. Tremblay and A. S. Slutsky, “Ventilator-induced lung injury: from the bench to the bedside,” Intensive Care Medicine, vol. 32, no. 1, pp. 24–33, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. P. E. Parsons, M. D. Eisner, B. T. Thompson et al., “Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury,” Critical Care Medicine, vol. 33, no. 1, pp. 1–6, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. N. E. Vlahakis, M. A. Schroeder, A. H. Limper, and R. D. Hubmayr, “Stretch induces cytokine release by alveolar epithelial cells in vitro,” American Journal of Physiology, vol. 277, no. 1, pp. L167–L173, 1999. View at Google Scholar · View at Scopus
  28. M. K. Connolly, A. S. Bedrosian, A. Malhotra et al., “In hepatic fibrosis, liver sinusoidal endothelial cells acquire enhanced immunogenicity,” Journal of Immunology, vol. 185, no. 4, pp. 2200–2208, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Raabe, M. Bukrinsky, and R. A. Currie, “Relative contribution of transcription and translation to the induction of tumor necrosis factor-α by lipopolysaccharide,” The Journal of Biological Chemistry, vol. 273, no. 2, pp. 974–980, 1998. View at Publisher · View at Google Scholar · View at Scopus
  30. K. J. Bosma, R. Taneja, and J. F. Lewis, “Pharmacotherapy for prevention and treatment of acute respiratory distress syndrome: current and experimental approaches,” Drugs, vol. 70, no. 10, pp. 1255–1282, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. P. Agouridakis, D. Kyriakou, M. G. Alexandrakis et al., “The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome,” Respiratory Research, vol. 3, article 25, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. K. D. Liu, D. V. Glidden, M. D. Eisner et al., “Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury,” Critical Care Medicine, vol. 35, no. 12, pp. 2755–2761, 2007. View at Google Scholar · View at Scopus
  33. V. M. Ranieri, P. M. Suter, C. Tortorella et al., “Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial,” JAMA, vol. 282, no. 1, pp. 54–61, 1999. View at Publisher · View at Google Scholar · View at Scopus