Research Article

Lung-Derived Mediators Induce Cytokine Production in Downstream Organs via an NF-κB-Dependent Mechanism

Table 1

Cytokine concentration in lung perfusate samples collected from animals sustaining ventilator-induced inflammation at the completion of 2 hours of mechanical ventilation using the isolated perfused mouse lung model. New uncirculated perfusate was used as the blank control for the ELISA. Values represent mean ± SEM.

Mediator Increase over control (pg/mL)

G-CSF21.87 4.57
IL-6267.81 28.35
KC356.38 57.98
MIP2198.70 12.24
MCP-12.01 1.54
TNF- 33.16 4.55
IFN- 1.44 0.88
IL-1 0.51 0.35
IL100.95 0.62
Eotaxin17.46 2.93