Research Article

Asymmetric Dimethylarginine Blocks Nitric Oxide-Mediated Alcohol-Stimulated Cilia Beating

Figure 2

ADMA blocks alcohol-stimulated increases in both CBF and PKA activity in bovine bronchial epithelial cells. Cilia beat frequency (CBF) in ciliated mouse tracheal rings treated with 10 μM–10 mM asymmetric dimethylarginine (ADMA) for up to 6 hr. ADMA had no effect on baseline CBF versus control media at any time point. Bars represent SEM of triplicate independent experiments ( mice) measuring at least 10 separate fields per experiment.
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