Figure 2: Osteopontin protein levels in the cerebrospinal fluid (CSF) of each group patients. The horizontal lines represent the mean values of each group, and asterisks show statistical significance ( ). (a) Osteopontin concentrations in CSF of 20 other noninflammatory neurologic diseases (OND), 18 clinically stable mild cognitive impairment patients (MCInc), 13 mild cognitive impairment converters (MCIc), 17 newly diagnosed AD (ADn), and 18 chronical AD patients (ADc) were determined using an enzyme-linked immunosorbent assay (ELISA). (b) The CSF osteopontin concentrations within the same individual ( ) at different disease statuses.