IL-10 Treatment Is Associated with Prohibitin Expression in the Crohn’s Disease Intestinal Fibrosis Mouse Model
Figure 3
Masson’s trichrome stain (×400) indicates that collagen deposition (blue) is located mainly in the mesenchymal, mucosa layer, submucosal areas, and muscularis propria in IL-10KO mice at 12 (d), 14 (e), and 16 (f) wk. Little collagen deposition was found in the mesenchymal layer in WT mice (a). IL-10KO treated with IL-10 5 μg/kg body weight, three times per week at 14 (b) and 16 (c), have less collagen in the submucosal areas and muscularis propria.
