Research Article
IL-10 Treatment Is Associated with Prohibitin Expression in the Crohn’s Disease Intestinal Fibrosis Mouse Model
Table 2
Gene expression of prohibitin, Nrf2, collagen I,
-SMA, and TGF-
β1
.
| Group-week | n | Prohibitin | TGF-β1 | Nrf2 | Collagen I | α-SMA |
| 12 wk | | | | | | | Control | 6 | 4.60 ± 0.72 | 0.32 ± 0.15 | 1.58 ± 1.01 | 0.45 ± 0.24 | 0.36 ± 0.43 | IL-10KO | 6 | 0.74 ± 0.15a | 1.12 ± 0.22a | 0.92 ± 0.42a | 1.13 ± 0.21a | 0.98 ± 0.48a | 14 wk | | | | | | | Control | 6 | 5.10 ± 1.32 | 0.28 ± 0.16 | 1.21 ± 0.64 | 0.40 ± 0.33 | 0.47 ± 0.13 | IL-10KO | 6 | 0.53 ± 0.22a | 1.48 ± 0.24a | 0.46 ± 0.27a | 1.68 ± 0.51a | 1.58 ± 0.36a | IL-10 treated | 6 | 1.85 ± 0.41ab | 0.62 ± 0.12ab | 1.09 ± 0.49ab | 1.10 ± 0.49ab | 1.18 ± 0.11ab | 16 wk | | | | | | | Control | 6 | 4.94 ± 1.05 | 0.31 ± 0.20 | 1.62 ± 0.85 | 0.42 ± 0.24 | 0.42 ± 0.33 | IL-10KO | 6 | 0.42 ± 0.03a | 1.91 ± 0.55a | 0.32 ± 0.15a | 1.88 ± 0.27a | 1.91 ± 0.95a | IL-10 treated | 6 | 2.51 ± 0.28b | 0.33 ± 0.10b | 2.13 ± 1.04b | 0.76 ± 0.25ab | 0.81 ± 0.50ab |
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, versus control group; b, versus IL-10KO mice group.
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