Characterization of Macrophage Phenotypes in Three Murine Models of House-Dust-Mite-Induced Asthma
Figure 3
(a) HDM exposure induced higher percentages of effector T cells in lung tissue of males (♂) and females (♀) as compared to control. Higher percentages of effector T cells were found in the 24-day protocol as compared to the 14- and 21-day protocol of HDM exposure. Combining all models, HDM exposure induced higher percentages of effector T cells in females than in males (). (b) HDM exposure induced higher percentages of regulatory T cells in lung tissue of males and females as compared to control. Higher percentages of regulatory T cells were found in the 24-day protocol as compared to the 14-day protocol of HDM exposure. Combining all models, HDM exposure induced higher percentages of regulatory T cells in females than in males (). (c) The 24-day protocol had higher ratios of effector T cells to regulatory T cells in lung tissue of males and females as compared to control and the 14- and 21-day protocols of HDM exposure. Combining all models, no differences were found between males and females. #, ## and ### compared to control. *, ** and ***.
