The Role of EGFR/PI3K/Akt/cyclinD1 Signaling Pathway in Acquired Middle Ear Cholesteatoma
Immunohistochemical staining of p-EGFR ((a), (b)), p-Akt ((c), (d)), cyclinD1 ((e), (f)), and PCNA ((g), (h)) in paraffin sections of human cholesteatoma epithelium ((a), (c), (e), (g)) and normal EAC skin epithelium ((b), (d), (f), (h)). In the figure, the keratin debris (K), matrix epithelium (M), and perimatrix subepithelial tissue (P) of cholesteatoma and the epithelium (EP) and subepithelial tissue (ST) of normal EAC skin are indicated. Original magnification: ×200.
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