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Mediators of Inflammation
Volume 2013 (2013), Article ID 684237, 10 pages
http://dx.doi.org/10.1155/2013/684237
Clinical Study

Expression of Inflammation-Related Genes Is Altered in Gastric Tissue of Patients with Advanced Stages of NAFLD

1Betty and Guy Beatty Obesity and Liver Program, Inova Health System, Falls Church, VA 22042, USA
2Center for the Study of Chronic Metabolic Diseases, School of Systems Biology, College of Science, George Mason University, Fairfax, VA 22030, USA
3Center for Liver Diseases and Department of Medicine, Inova Fairfax Hospital, Falls Church, VA 22042, USA

Received 15 December 2012; Revised 12 February 2013; Accepted 14 February 2013

Academic Editor: David Bernardo Ordiz

Copyright © 2013 Rohini Mehta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. S. Flier and E. Maratos-Flier, “Obesity and the hypothalamus: novel peptides for new pathways,” Cell, vol. 92, no. 4, pp. 437–440, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. K. E. Kypreos, I. Karagiannides, E. H. Fotiadou et al., “Mechanisms of obesity and related pathologiesrRole of apolipoprotein e in the development of obesity,” FEBS Journal, vol. 276, no. 20, pp. 5720–5728, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Dobrin, J. Zhu, C. Molony et al., “Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease,” Genome Biology, vol. 10, no. 5, article R55, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Baranova, S. J. Gowder, K. Schlauch et al., “Gene expression of leptin, resistin, and adiponectin in the white adipose tissue of obese patients with non-alcoholic fatty liver disease and insulin resistance,” Obesity Surgery, vol. 16, no. 9, pp. 1118–1125, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. G. J. Morton and M. W. Schwartz, “Leptin and the central nervous system control of glucose metabolism,” Physiological Reviews, vol. 91, no. 2, pp. 389–411, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. U. Gurriarán-Rodríguez, O. Al-Massadi, A. Roca-Rivada et al., “Obestatin as a regulator of adipocyte metabolism and adipogenesis,” Journal of Cellular and Molecular Medicine, vol. 15, pp. 1927–1940, 2011. View at Google Scholar
  7. M. Estep, M. Abawi, M. Jarrar et al., “Association of obestatin, ghrelin, and inflammatory cytokines in obese patients with non-alcoholic fatty liver disease,” Obesity Surgery, vol. 21, pp. 1750–1757, 2011. View at Google Scholar
  8. O. B. Chaudhri, B. C. T. Field, and S. R. Bloom, “Gastrointestinal satiety signals,” International Journal of Obesity, vol. 32, pp. S28–S31, 2008. View at Google Scholar
  9. M. H. Jarrar, A. Baranova, R. Collantes et al., “Adipokines and cytokines in non-alcoholic fatty liver disease,” Alimentary Pharmacology and Therapeutics, vol. 27, no. 5, pp. 412–421, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. N. M. W. de Alwis and C. P. Day, “Non-alcoholic fatty liver diseasetThe mist gradually clears,” Journal of Hepatology, vol. 48, supplement 1, pp. S104–S112, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. C. H. Kim and Z. M. Younossi, “Nonalcoholic fatty liver disease: a manifestation of the metabolic syndrome,” Cleveland Clinic Journal of Medicine, vol. 75, no. 9, pp. 673–680, 2008. View at Google Scholar · View at Scopus
  12. M. Machado, P. Marques-Vidal, and H. Cortez-Pinto, “Hepatic histology in obese patients undergoing bariatric surgery,” Journal of Hepatology, vol. 45, no. 4, pp. 600–606, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Vernon, A. Baranova, and Z. M. Younossi, “Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults,” Alimentary Pharmacology and Therapeutics, vol. 34, no. 3, pp. 274–285, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. D. E. Cummings and J. Overduin, “Gastrointestinal regulation of food intake,” Journal of Clinical Investigation, vol. 117, no. 1, pp. 13–23, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. S. C. Woods, “Gastrointestinal Satiety Signals. I. An overview of gastrointestinal signals that influence food intake,” American Journal of Physiology, vol. 286, no. 1, pp. G7–G13, 2004. View at Google Scholar · View at Scopus
  16. M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa, “Ghrelin is a growth-hormone-releasing acylated peptide from stomach,” Nature, vol. 402, no. 6762, pp. 656–660, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. J. V. Zhang, P. G. Ren, O. Avsian-Kretchmer et al., “Medicine: obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake,” Science, vol. 310, no. 5750, pp. 996–999, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Cinti, R. De Matteis, E. Ceresi et al., “Leptin in the human stomach,” Gut, vol. 49, no. 1, article 155, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. P. G. Cammisotto, É. Levy, L. J. Bukowiecki, and M. Bendayan, “Cross-talk between adipose and gastric leptins for the control of food intake and energy metabolism,” Progress in Histochemistry and Cytochemistry, vol. 45, no. 3, pp. 142–200, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. P. G. Cammisotto, C. Renaud, D. Gingras, E. Delvin, E. Levy, and M. Bendayan, “Endocrine and exocrine secretion of leptin by the gastric mucosa,” Journal of Histochemistry and Cytochemistry, vol. 53, no. 7, pp. 851–860, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Jeffery, V. McDonald, E. Tippett, and M. McGuckin, “Ghrelin in gastrointestinal disease,” Molecular and Cellular Endocrinology, vol. 340, no. 1, pp. 35–43, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Baatar, K. Patel, and D. D. Taub, “The effects of ghrelin on inflammation and the immune system,” Molecular and Cellular Endocrinology, vol. 340, pp. 44–58, 2011. View at Google Scholar
  23. J. Ye, G. Coulouris, I. Zaretskaya, I. Cutcutache, S. Rozen, and T. L. Madden, “Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction,” BMC Bioinformatics, vol. 13, article 134, 2012. View at Google Scholar
  24. T. D. Schmittgen and K. J. Livak, “Analyzing real-time PCR data by the comparative CT method,” Nature Protocols, vol. 3, no. 6, pp. 1101–1108, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Vandesompele, K. De Preter, F. Pattyn et al., “Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes,” Genome Biology, vol. 3, no. 7, Article ID RESEARCH0034, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Birerdinc, R. Mehta, M. Stepanova et al., Gastric Tissue Gene Expression Associated with Obesity-Related Non-Alcoholic Steatohepatitis (NASH), American Association for the Study of Liver Diseases, 2010.
  27. K. F. Petersen, S. Dufour, D. Befroy, M. Lehrke, R. E. Hendler, and G. I. Shulman, “Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes,” Diabetes, vol. 54, no. 3, pp. 603–608, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Tilg and A. R. Moschen, “Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis,” Hepatology, vol. 52, no. 5, pp. 1836–1846, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. J. M. Estep, A. Baranova, N. Hossain et al., “Expression of cytokine signaling genes in morbidly obese patients with non-alcoholic steatohepatitis and hepatic fibrosis,” Obesity Surgery, vol. 19, no. 5, pp. 617–624, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Baranova, M. Randhawa, M. Jarrar, and Z. M. Younossi, “Adipokines and melanocortins in the hepatic manifestation of metabolic syndrome: nonalcoholic fatty liver disease,” Expert Review of Molecular Diagnostics, vol. 7, no. 2, pp. 195–205, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Baranova, K. Schlauch, S. Gowder, R. Collantes, V. Chandhoke, and Z. M. Younossi, “Microarray technology in the study of obesity and non-alcoholic fatty liver disease,” Liver International, vol. 25, no. 6, pp. 1091–1096, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. H. W. Zimmermann, S. Seidler, N. Gassler et al., “Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis,” PLoS ONE, vol. 6, no. 6, Article ID e21381, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Kuboki, T. Shin, N. Huber et al., “Hepatocyte signaling through CXC chemokine receptor-2 is detrimental to liver recovery after ischemia/reperfusion in mice,” Hepatology, vol. 48, no. 4, pp. 1213–1223, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. R. C. Chou, N. D. Kim, C. D. Sadik et al., “Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis,” Immunity, vol. 33, no. 2, pp. 266–278, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. L. Gómez-Quiroz, L. Bucio, V. Souza et al., “Interleukin 8 response and oxidative stress in HepG2 cells treated with ethanol, acetaldehyde or lipopolysaccharide,” Hepatology Research, vol. 26, no. 2, pp. 134–141, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Böni-Schnetzler, S. Boller, S. Debray et al., “Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I,” Endocrinology, vol. 150, no. 12, pp. 5218–5229, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. A. Andoh, H. Takaya, Y. Araki, T. Tsujikawa, Y. Fujiyama, and T. Bamba, “Medium- and long-chain fatty acids differentially modulate interleukin-8 secretion in human fetal intestinal epithelial cells,” Journal of Nutrition, vol. 130, no. 11, pp. 2636–2640, 2000. View at Google Scholar · View at Scopus
  38. J. Pihlajamäki, T. Kuulasmaa, D. Kaminska et al., “Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans,” Journal of Hepatology, vol. 56, pp. 663–670, 2012. View at Google Scholar
  39. S. Perrier, F. Darakhshan, and E. Hajduch, “IL-1 receptor antagonist in metabolic diseases: Dr Jekyll or Mr Hyde?” FEBS Letters, vol. 580, no. 27, pp. 6289–6294, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. C. Gabay, M. F. Smith, D. Eidlen, and W. P. Arend, “Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein,” Journal of Clinical Investigation, vol. 99, no. 12, pp. 2930–2940, 1997. View at Google Scholar · View at Scopus
  41. W. P. Arena, M. Malyak, C. J. Guthridge, and C. Gabay, “Interleukin-1 receptor antagonist: role in biology,” Annual Review of Immunology, vol. 16, pp. 27–55, 1998. View at Publisher · View at Google Scholar · View at Scopus
  42. E. Somm, P. Cettour-Rose, C. Asensio et al., “Interleukin-1 receptor antagonist is upregulated during diet-induced obesity and regulates insulin sensitivity in rodents,” Diabetologia, vol. 49, no. 2, pp. 387–393, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. A. Beilhack and S. G. Rockson, “Immune traffic: a functional overview.,” Lymphatic research and biology, vol. 1, no. 3, pp. 219–234, 2003. View at Google Scholar · View at Scopus
  44. A. Bertola, S. Bonnafous, R. Anty et al., “Hepatic expression patterns of inflammatory and immune response genes associated with obesity and nash in morbidly obese patients,” PLoS ONE, vol. 5, no. 10, Article ID e13577, 2010. View at Publisher · View at Google Scholar · View at Scopus