Hmgb1-IL-23-IL-17-IL-6-Stat3 Axis Promotes Tumor Growth in Murine Models of Melanoma
The Hmgb1-RAGE pathway mediates the production of IL-23. (a) mRNA levels of Hmgb1 and RAGE were analyzed by realtime PCR in tumor tissues from tumor-bearing mice one or two weeks after B16-F10 inoculation (). (b) Hmgb1 and RAGE mRNA levels were analyzed by realtime PCR in tumor tissues two weeks after B16-F10 inoculation from WT, WT + anti-γ δ TCR, and IL-17−/− groups (). (c) Tumor growth in B16 tumor-bearing wild-type mice treated i.p. with 10 mg/mouse glycyrrhizin (GL) on days 0, 2, 5, 10, and 15 and B16 tumor-bearing RAGE−/− mice (). (d) IL-23p19 and IL-17 relative mRNA expression in tumor tissues from B16-F10 tumor-bearing wild-type mice and RAGE−/− mice (). (e) IL-23p19 and IL-17 relative mRNA expression in tumor tissues from B16-F10 tumor-bearing wild-type mice treated with GL or GL + Ad-IL-23 or left untreated (). (f) Tumor growth in B16 tumor-bearing wild-type mice treated with GL, or GL + Ad-IL-23, GL + Ad-GFP or left untreated (). The data show means ± SEM of tumor size and are representative of three independent experiments. .
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