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Mediators of Inflammation
Volume 2013, Article ID 720536, 19 pages
Research Article

Progression of Luminal Breast Tumors Is Promoted by Ménage à Trois between the Inflammatory Cytokine TNFα and the Hormonal and Growth-Supporting Arms of the Tumor Microenvironment

Ela Kodesz Institute for Research on Cancer Development and Prevention, Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978 Tel Aviv, Israel

Received 21 August 2013; Accepted 9 October 2013

Academic Editor: Salahuddin Ahmed

Copyright © 2013 Polina Weitzenfeld et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1: Combined stimulation by TNFα+Estrogen+EGF is more effective than Estrogen+TNFα or Estrogen+EGF in inducing extensive morphological changes and spreading in breast tumor cells.

Supplementary Figure 2: Combined stimulation by TNFα+Estrogen+EGF leads to reduced viability of breast tumor cells in culture.

Supplementary Figure 3: Breast tumor cells that migrated out of tumor-spheroids following TNFα+Estrogen+EGF stimulation, express reduced levels of E-cadherin.

  1. Supplementary Figures