Inhibitory Effect of Matrine on Blood-Brain Barrier Disruption for the Treatment of Experimental Autoimmune Encephalomyelitis

Figure 5

Serum concentration of MMP-9 and TIMP-1. At day 17 p.i., sera were harvested from treated and nontreated EAE rats, with sera from naive rats serving as control. MMP-9 and TIMP-1 production was determined by ELISA. Results are expressed as mean ± SD (𝑛=8 each group). ^△△𝑃<0.01, compared to naive group; ^∗∗𝑃<0.01, compared to the vehicle group; ^##𝑃<0.01, compared to the DEX group; ^◊◊𝑃<0.01, comparison between MAT-L and MAT-H groups.