Research Article

Cannabinoid Receptor 2 Protects against Acute Experimental Sepsis in Mice

Figure 2

GW405833 inhibits ConA-induced splenocytes proliferation partially via CB2R activation. (a) Splenocytes isolated from CB2R+/+ mice were treated vehicle or ConA (5 μg/mL) in the absence or presence of GW405833 (1–10  M) for 24 h. Splenocytes proliferation was detected by CCK-8. Data are means SD ( ) and ** . (b) Splenocytes isolated from CB2R+/+ and CB2R−/− mice were treated with ConA (5  g/mL) in the absence or presence of GW405833 (10  M) for 24 h. Splenocytes proliferation was detected by CCK-8. Data are means SD ( ) and ** .
741303.fig.002a
(a)
741303.fig.002b
(b)