Biphasic Modulation of NOS Expression, Protein and Nitrite Products by Hydroxocobalamin Underlies Its Protective Effect in Endotoxemic Shock: Downstream Regulation of COX-2, IL-1𝜷, TNF-𝜶, IL-6, and HMGB1 Expression

Table 3

Effects of the naturally occurring endogenous cobalamins in the NF-𝜅B gene reporter assay.

Treatments	NF-𝜅B reporter assay (fold increase over basal)
	1 h	24 h
LPS	5.63 ± 0.37	4.60 ± 0.21
CNCbl (𝜇M)
1	*7.10 ± 0.30	5.70 ± 0.90
10	5.53 ± 0.29	6.60 ± 1.70
100	5.23 ± 0.62	5.53 ± 0.74
GSCbl (𝜇M)
1	6.33 ± 0.37	5.66 ± 0.67
10	6.25 ± 0.32	5.63 ± 0.63
100	5.98 ± 0.26	5.17 ± 0.84
MeCbl (𝜇M)
1	6.10 ± 0.10	6.53 ± 1.74
10	6.10 ± 0.15	5.11 ± 1.06
100	6.00 ± 0.58	5.26 ± 0.62
HOCbl (𝜇M)
1	5.67 ± 0.20	5.73 ± 0.91
10	5.98 ± 0.26	5.57 ± 0.78
100	7.00 ± 1.10	6.10 ± 0.66
AdoCbl (𝜇M)
1	6.23 ± 0.39	5.36 ± 0.77
10	6.26 ± 0.90	5.40 ± 0.70
100	6.20 ± 0.61	4.53 ± 0.32