Alcohol-Induced Liver Injury Is Modulated by Nlrp3 and Nlrc4 Inflammasomes in Mice

Figure 3

CYP2E1 induction with alcohol consumption. (a) western blot analysis of proteins from livers isolated from C57BL/6J (B6), Nlrp3^−/−, and Nlrc4^−/− mice fed ethanol-containing diet (EtOH-Fed) or pair-fed diet (Pair-fed). Westerns were normalized with heat shock cognate-70 (HSC70) as a loading control. In the graph, densitometric scans of western blots were performed and analyzed. Values represent the mean ± SEM with **𝑃<0.05, ***𝑃<0.001 by Student’s 𝑡-test for 𝑛=4–6 mice per group.