Alcohol-Induced Liver Injury Is Modulated by Nlrp3 and Nlrc4 Inflammasomes in Mice

Figure 7

Altered IL-1β and IL-18 expression in the liver in Nlrp3^−/− and Nlrc4^−/− mice. Protein was isolated from livers of C57BL/6J (B6), Nlrp3^−/−, and Nlrc4^−/− mice fed Lieber-DeCarli ethanol-containing diet (EtOH-Fed) or pair-fed controls (Pair-Fed). Levels of IL-1β and IL-18 were measured using specific ELISA. Values represent the mean ± SEM with **𝑃<0.05, ***𝑃<0.001 by Student’s 𝑡-test for 𝑛=4–6 mice per group.