A Possible Role for CD8+ T Lymphocytes in the Cell-Mediated Pathogenesis of Pemphigus Vulgaris

<table>Incidence of disease in KO mice and control-C57BL/6 mice in passive transfer model of IgG PV. With a dose of 30 <i>μ</i>L/g PV plasma, 0% (0/5) of the CD8<sup>−</sup>/<sup>−</sup> mice developed PV, compared with 9.5% (4/42) of C57BL/6 mice. With an injected dose of 50 <i>μ</i>L/g, 44% (13/29) of the CD8<sup>−</sup>/<sup>−</sup> mice showed PV lesions, compared with 72% (26/36) of the control group.</table>

Mediators of Inflammation

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Figure 2

Figure 2: A Possible Role for CD8+ T Lymphocytes in the Cell-Mediated Pathogenesis of Pemphigus Vulgaris 