Macrophage Heterogeneity in Respiratory Diseases

Figure 1

Schematic representation of the three macrophage phenotypes and their characteristics. IFNγ: interferon gamma; TNFα: tumor necrosis factor alpha; LPS: lipopolysaccharide; MHC class II: major histocompatibility complex class II; IL: interleukin; NO: nitric oxide; IRF5: interferon regulatory factor 5; Fe: iron; TGM2: transglutaminase 2; YM1: chitinase-3-like protein-3; FIZZ1/Relmα: resistin-like molecule-α; Arg-1: arginase-1; TGFβ: transforming growth factor beta; TLR: Toll-like receptor; PGE2: prostaglandin E2; PPARγ: peroxisome proliferator-activated receptor gamma.